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Synthesis and Cytotoxic Evaluation of Pyrrole Hetarylazoles Containing Benzimidazole/Pyrazolone/1,3,4‐Oxadiazole Motifs
Author(s) -
Mochona Bereket,
Jackson Timothy,
McCauley DeCoria,
Mazzio Elizabeth,
Redda Kinfe K.
Publication year - 2016
Publication title -
journal of heterocyclic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.321
H-Index - 59
eISSN - 1943-5193
pISSN - 0022-152X
DOI - 10.1002/jhet.2501
Subject(s) - pyrazolone , benzimidazole , oxadiazole , chemistry , pyrrole , cytotoxicity , proton nmr , carbon 13 nmr , hydrazide , cytotoxic t cell , stereochemistry , combinatorial chemistry , in vitro , organic chemistry , biochemistry
Azomethine‐linked pyrrole bishetarylazoles containing benzimidazole/pyrazolone/1,3,4‐oxadiazole were synthesized in satisfactory yields. Their structures were confirmed by IR, 1 H‐NMR, 13 C‐NMR, and elemental analysis. Evaluation for the cytotoxic activities in vitro against a panel of breast cancer cell lines (MDA‐AB‐231, BT‐474, and Ishikawa cells) revealed that the pyrrole–benzimidazole hybrids are more potent than the pyrazolone and 1,3,4‐oxadiazole hybrids in all cell lines. Compound 9 displayed promising cytotoxicity against BT‐474 cell line with IC 50 values, 7.7 µ M .