Synthesis and Cytotoxic Evaluation of Pyrrole Hetarylazoles Containing Benzimidazole/Pyrazolone/1,3,4‐Oxadiazole Motifs | Zendy

Mochona Bereket | Zendy; Jackson Timothy | Zendy; McCauley DeCoria | Zendy; Mazzio Elizabeth | Zendy; Redda Kinfe K. | Zendy

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Synthesis and Cytotoxic Evaluation of Pyrrole Hetarylazoles Containing Benzimidazole/Pyrazolone/1,3,4‐Oxadiazole Motifs

Author(s) -

Mochona Bereket,

Jackson Timothy,

McCauley DeCoria,

Mazzio Elizabeth,

Redda Kinfe K.

Publication year - 2016

Publication title -

journal of heterocyclic chemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.321

H-Index - 59

eISSN - 1943-5193

pISSN - 0022-152X

DOI - 10.1002/jhet.2501

Subject(s) - pyrazolone , benzimidazole , oxadiazole , chemistry , pyrrole , cytotoxicity , proton nmr , carbon 13 nmr , hydrazide , cytotoxic t cell , stereochemistry , combinatorial chemistry , in vitro , organic chemistry , biochemistry

Azomethine‐linked pyrrole bishetarylazoles containing benzimidazole/pyrazolone/1,3,4‐oxadiazole were synthesized in satisfactory yields. Their structures were confirmed by IR, 1 H‐NMR, 13 C‐NMR, and elemental analysis. Evaluation for the cytotoxic activities in vitro against a panel of breast cancer cell lines (MDA‐AB‐231, BT‐474, and Ishikawa cells) revealed that the pyrrole–benzimidazole hybrids are more potent than the pyrazolone and 1,3,4‐oxadiazole hybrids in all cell lines. Compound 9 displayed promising cytotoxicity against BT‐474 cell line with IC 50 values, 7.7 µ M .

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