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Synthesis of New Bis‐1,2,4‐Oxadiazoline Derivatives via 1,3‐Dipolar Cycloaddition Reaction
Author(s) -
Chen Fei,
Zeng Hua,
Liu FangMing
Publication year - 2016
Publication title -
journal of heterocyclic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.321
H-Index - 59
eISSN - 1943-5193
pISSN - 0022-152X
DOI - 10.1002/jhet.2500
Subject(s) - chemistry , cycloaddition , aldimine , nitrile , 1,3 dipolar cycloaddition , mass spectrometry , organic chemistry , medicinal chemistry , combinatorial chemistry , catalysis , chromatography
A series of novel bis‐oxadiazoline derivatives 4 was synthesized via 1,3‐dipolar cycloaddition reaction of bis‐aldimines 3 , and nitrile oxides generated in situ from various benzohydroximinoyl chlorides in the presence of Et 3 N. The target products were confirmed by IR, 1 H‐NMR, and mass spectrometry .