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Synthesis and Biological Activities of 6‐Hydroxyaurone Derivatives
Author(s) -
Bao YongTuan,
Zhang Min,
Li Ting,
Xiao HuiFeng,
Zhao Ting,
Xu XiaoHua,
Yang LiuQing
Publication year - 2016
Publication title -
journal of heterocyclic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.321
H-Index - 59
eISSN - 1943-5193
pISSN - 0022-152X
DOI - 10.1002/jhet.2497
Subject(s) - chemistry , combinatorial chemistry , organic chemistry , stereochemistry
A series of 6‐hydroxyaurone derivatives were synthesized in satisfactory yields and characterized by IR, 1 H NMR, 13 C NMR, and HRMS or elemental analysis. The structure of compound 3e was further confirmed by X‐ray crystal analysis. Bioassay results indicated that some of the target compounds displayed moderate herbicidal activity against the dicotyledonous plant Brassica campestris L. at 100 µg·mL −1 , and some compounds also showed significant antiproliferative activity against tumor cell lines Hela, HepG‐2, and MCF‐7.