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Design, Multicomponent Synthesis and Characterization of Diversely Substituted Pyrazolo[1,5‐a] Pyrimidine Derivatives
Author(s) -
Ghelani Satish M.,
Naliapara Yogesh T.
Publication year - 2016
Publication title -
journal of heterocyclic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.321
H-Index - 59
eISSN - 1943-5193
pISSN - 0022-152X
DOI - 10.1002/jhet.2496
Subject(s) - chemistry , pyrimidine , aldehyde , combinatorial chemistry , pyrazole , isopropyl , isopropyl alcohol , stereochemistry , organic chemistry , catalysis
The synthesis of various heterocyclic compounds using acetoacetanilide[AAA], we have demonstrated that acetoactanilide are versatile intermediate for the synthesis of pyrazolopyrimidine derivatives. Thus, to explore further, we sought that the reaction of various acetoactanilide, an appropriate aldehyde and 5‐amino‐ N ‐cyclohexyl‐3‐(methylthio)‐1 H ‐pyrazole‐4‐carboxamide in the presence of base in isopropyl alcohol could be an effective strategy to furnish the novel pyrazolopyrimidine derivatives. Here we describe the novel synthetic methodology for the fused pyrazolopyrimidines.