AgNO 3  Catalyzed Regio‐Selective Synthesis of 3‐Alkyl/Aryl‐idene‐3,4‐dihydro‐4‐tosyl‐2H‐1,4‐Benzoxazine: Novel Anti‐Tubercular Scaffolds | Zendy

Karunanidhi Sivanandhan | Zendy; Karpoormath Rajshekhar | Zendy; Bera Milan | Zendy; Rane Rajesh A. | Zendy; Palkar Mahesh B. | Zendy

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AgNO 3 Catalyzed Regio‐Selective Synthesis of 3‐Alkyl/Aryl‐idene‐3,4‐dihydro‐4‐tosyl‐2H‐1,4‐Benzoxazine: Novel Anti‐Tubercular Scaffolds

Author(s) -

Karunanidhi Sivanandhan,

Karpoormath Rajshekhar,

Bera Milan,

Rane Rajesh A.,

Palkar Mahesh B.

Publication year - 2016

Publication title -

journal of heterocyclic chemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.321

H-Index - 59

eISSN - 1943-5193

pISSN - 0022-152X

DOI - 10.1002/jhet.2472

Subject(s) - chemistry , aryl , alkyl , catalysis , tosyl , combinatorial chemistry , mycobacterium tuberculosis , stereochemistry , medicinal chemistry , organic chemistry , tuberculosis , medicine , pathology

A facile and efficient method for the construction of 3‐alkyl/aryl substituted 1,4‐benzoxazine and benzoxazepine via AgNO 3 catalyzed cyclization of propargyloxy sulfonamides and their anti‐tubercular activity against Mycobacterium tuberculosis H 37 R V is described. This cyclization proceeds through 6‐ exo ‐dig manner to generate the products in moderate to good yields.

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