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AgNO 3 Catalyzed Regio‐Selective Synthesis of 3‐Alkyl/Aryl‐idene‐3,4‐dihydro‐4‐tosyl‐2H‐1,4‐Benzoxazine: Novel Anti‐Tubercular Scaffolds
Author(s) -
Karunanidhi Sivanandhan,
Karpoormath Rajshekhar,
Bera Milan,
Rane Rajesh A.,
Palkar Mahesh B.
Publication year - 2016
Publication title -
journal of heterocyclic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.321
H-Index - 59
eISSN - 1943-5193
pISSN - 0022-152X
DOI - 10.1002/jhet.2472
Subject(s) - chemistry , aryl , alkyl , catalysis , tosyl , combinatorial chemistry , mycobacterium tuberculosis , stereochemistry , medicinal chemistry , organic chemistry , tuberculosis , medicine , pathology
A facile and efficient method for the construction of 3‐alkyl/aryl substituted 1,4‐benzoxazine and benzoxazepine via AgNO 3 catalyzed cyclization of propargyloxy sulfonamides and their anti‐tubercular activity against Mycobacterium tuberculosis H 37 R V is described. This cyclization proceeds through 6‐ exo ‐dig manner to generate the products in moderate to good yields.