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Synthesis and in vitro Antimicrobial Activity of Nalidixic Acid Hydrazones
Author(s) -
Popiołek Łukasz,
Biernasiuk Anna,
Malm Anna
Publication year - 2016
Publication title -
journal of heterocyclic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.321
H-Index - 59
eISSN - 1943-5193
pISSN - 0022-152X
DOI - 10.1002/jhet.2468
Subject(s) - chemistry , nalidixic acid , antimicrobial , bacteria , broth microdilution , microbiology and biotechnology , minimum inhibitory concentration , organic chemistry , biochemistry , biology , antibiotics , antibiotic resistance , genetics
A series of nalidixic acid‐based hydrazones have been synthesized and evaluated for their in vitro antimicrobial activity using the broth microdilution method against a panel of reference strains of microorganisms, including Gram‐positive bacteria, Gram‐negative bacteria, and fungi belonging to yeasts Candida spp. and molds Aspergillus spp., Penicillium spp., and Rhizopus spp. Nalidixic acid derivatives were obtained by condensation reaction of nalidixic acid hydrazide with substituted (hetero)aromatic aldehydes. All compounds have been characterized by 1 H NMR and 13 C NMR spectra. The antimicrobial activity indicated that compound with indole substituent could be a promising lead for future development of active antifungal agents .