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An Improved Protocol for Synthesis of 3‐Substituted 5‐Arylidene‐2‐thiohydantoins: Two‐step Procedure Alternative to Classical Methods
Author(s) -
Kuznetsova Olga Yu,
Antipin Roman L.,
Udina Anna V.,
Krasnovskaya Olga O.,
Beloglazkina Elena K.,
Terenin Vladimir I.,
Koteliansky Victor E.,
Zyk Nikolay V.,
Majouga Alexander G.
Publication year - 2016
Publication title -
journal of heterocyclic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.321
H-Index - 59
eISSN - 1943-5193
pISSN - 0022-152X
DOI - 10.1002/jhet.2464
Subject(s) - chemistry , base (topology) , combinatorial chemistry , protocol (science) , organic chemistry , medicine , mathematical analysis , alternative medicine , mathematics , pathology
A novel method for the direct synthesis of 5‐arylidene‐2‐thiohydantoins from thioureas and aromatic aldehydes in the presence of base in ethanol was developed. Application of this efficient method allowed preparing thiohydantoins, which are difficult to synthesis by traditional methods.