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Microwave‐assisted Regioselective Synthesis of Novel Bis(azoles) and Bis(azoloazines)
Author(s) -
AlBogami Abdullah S.,
Mekky Ahmed E. M.
Publication year - 2016
Publication title -
journal of heterocyclic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.321
H-Index - 59
eISSN - 1943-5193
pISSN - 0022-152X
DOI - 10.1002/jhet.2462
Subject(s) - regioselectivity , chemistry , structural isomer , microwave irradiation , cycloaddition , combinatorial chemistry , microwave , computational chemistry , stereochemistry , organic chemistry , catalysis , physics , quantum mechanics
We introduce efficient regioselective synthesis of a series of novel bis(pyrazoles) and bis(isoxazoles) via 1,3‐dipolar cycloaddition reaction under microwave irradiation . Unequivocal structural assignment of the obtained regioisomers was determined utilizing 1 H‐ 13 C HMBC NMR techniques as a valuable tool. A comparative study of the aforementioned reactions was carried out under conventional method as well as under microwave irradiation conditions.