Premium
Utilization of 2(3 H )‐Furanone Bearing a Pyrazolyl Side Chain for the Construction of a Variety of Thiazolidinone Derivatives
Author(s) -
AbouElmagd Wael S. I.,
Hashem Ahmed I.
Publication year - 2016
Publication title -
journal of heterocyclic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.321
H-Index - 59
eISSN - 1943-5193
pISSN - 0022-152X
DOI - 10.1002/jhet.2456
Subject(s) - thioglycolic acid , chemistry , benzene , derivative (finance) , decomposition , organic chemistry , combinatorial chemistry , economics , financial economics
2(3 H )‐Furanone 1 was utilized for the construction of thiazolidinone derivatives. Thus, upon treatment the cyano derivatives 5 with thioglycolic acid afforded the thiazolidinone derivatives 6 . Reaction of the Schiff base derivative 9 with thioglycolic acid gave the thiazolidinone derivative 10 . Decomposition of the azides 11 in dry benzene in the presence of thioglycolic acid gave the thiazolidindione derivative 12 . Antimicrobial activities of synthesized compounds were tested. Some of the tested compounds showed promising activities.