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Synthesis of Pyrazolyl‐Pyrazoles and Pyrazolyl‐[1,2,4]‐Triazolo[3,4‐ d ][1,5]Benzothiazepines as p53 Activators Using Hydrazonoyl Chlorides
Author(s) -
Gomha Sobhi M.,
Farghaly Thoraya A.,
Sayed Abdelwahed R.,
Abdalla Mohamed M.
Publication year - 2016
Publication title -
journal of heterocyclic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.321
H-Index - 59
eISSN - 1943-5193
pISSN - 0022-152X
DOI - 10.1002/jhet.2455
Subject(s) - chemistry , pyrazole , combinatorial chemistry , medicinal chemistry , stereochemistry
Di ‐pyrazoles, tripyrazoles, and pyrazolyltriazolobenzothiazepines were prepared from α ,β‐unsaturated ketones and hydrazonoyl chlorides. The structure of all the newly synthesized compounds was established on the bases of their spectral data and elemental analyses. The activity of all products was examined as p53 ubiquitination which showed promising activities.