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5‐Hydroxyl Hydantoins via One‐Pot Microwave‐Assisted Air Oxidation of Ugi Products
Author(s) -
Huang Adrian,
Wo Kellie,
Pierson Allene,
Lee So Yeun Christine,
Yang Erin,
Johnson Catherine
Publication year - 2016
Publication title -
journal of heterocyclic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.321
H-Index - 59
eISSN - 1943-5193
pISSN - 0022-152X
DOI - 10.1002/jhet.2454
Subject(s) - chemistry , pharmacophore , combinatorial chemistry , isocyanide , microwave , condensation , microwave heating , ugi reaction , organic chemistry , stereochemistry , physics , quantum mechanics , thermodynamics
The novel and one‐pot synthesis of 5‐hydroxyl hydantoins from Ugi five‐component condensation procedures is reported. The transformation was promoted via a microwave heating method and provided 5‐hydroxyl hydantoins in workable yields, representing a direct approach to this synthetically challenging and biologically interesting pharmacophore.