5‐Hydroxyl Hydantoins via One‐Pot Microwave‐Assisted Air Oxidation of Ugi Products | Zendy

Huang Adrian | Zendy; Wo Kellie | Zendy; Pierson Allene | Zendy; Lee So Yeun Christine | Zendy; Yang Erin | Zendy; Johnson Catherine | Zendy

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5‐Hydroxyl Hydantoins via One‐Pot Microwave‐Assisted Air Oxidation of Ugi Products

Author(s) -

Huang Adrian,

Wo Kellie,

Pierson Allene,

Lee So Yeun Christine,

Yang Erin,

Johnson Catherine

Publication year - 2016

Publication title -

journal of heterocyclic chemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.321

H-Index - 59

eISSN - 1943-5193

pISSN - 0022-152X

DOI - 10.1002/jhet.2454

Subject(s) - chemistry , pharmacophore , combinatorial chemistry , isocyanide , microwave , condensation , microwave heating , ugi reaction , organic chemistry , stereochemistry , physics , quantum mechanics , thermodynamics

The novel and one‐pot synthesis of 5‐hydroxyl hydantoins from Ugi five‐component condensation procedures is reported. The transformation was promoted via a microwave heating method and provided 5‐hydroxyl hydantoins in workable yields, representing a direct approach to this synthetically challenging and biologically interesting pharmacophore.

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