Premium
A Practical and Scalable Synthesis of GTx‐134, an IGF‐1R Inhibitor
Author(s) -
Liu Yahu A.,
Gregor Vlad E.
Publication year - 2016
Publication title -
journal of heterocyclic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.321
H-Index - 59
eISSN - 1943-5193
pISSN - 0022-152X
DOI - 10.1002/jhet.2443
Subject(s) - chemistry , scalability , small molecule , multiple myeloma , combinatorial chemistry , insulin like growth factor , cancer research , pharmacology , receptor , growth factor , biochemistry , medicine , computer science , database , biology
A practical and scalable synthesis of GTx‐134, a novel small‐molecule inhibitor of insulin‐like growth factor 1 receptor showing antitumor activity in preclinical models of multiple myeloma, is reported.