Premium
A Practical and Scalable Synthesis of GTx‐134, an IGF‐1R Inhibitor
Author(s) -
Liu Yahu A.,
Gregor Vlad E.
Publication year - 2016
Publication title -
journal of heterocyclic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.321
H-Index - 59
eISSN - 1943-5193
pISSN - 0022-152X
DOI - 10.1002/jhet.2443
Subject(s) - chemistry , scalability , small molecule , multiple myeloma , combinatorial chemistry , insulin like growth factor , cancer research , pharmacology , receptor , growth factor , biochemistry , medicine , computer science , database , biology
A practical and scalable synthesis of GTx‐134, a novel small‐molecule inhibitor of insulin‐like growth factor 1 receptor showing antitumor activity in preclinical models of multiple myeloma, is reported.
Accelerating Research
Robert Robinson Avenue,
Oxford Science Park, Oxford
OX4 4GP, United Kingdom
Address
John Eccles HouseRobert Robinson Avenue,
Oxford Science Park, Oxford
OX4 4GP, United Kingdom