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Synthesis, Dissociation Constants, and Antimicrobial Activity of Novel 2,3‐Disubstituted‐1,3‐thiazolidin‐4‐one Derivatives
Author(s) -
Popiołek Łukasz,
Stefańska Joanna,
Kiełczykowska Małgorzata,
Musik Irena,
Biernasiuk Anna,
Malm Anna,
Wujec Monika
Publication year - 2016
Publication title -
journal of heterocyclic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.321
H-Index - 59
eISSN - 1943-5193
pISSN - 0022-152X
DOI - 10.1002/jhet.2418
Subject(s) - chemistry , antimicrobial , hydrazide , dissociation constant , broth microdilution , antifungal , proton nmr , antibacterial activity , combinatorial chemistry , organic chemistry , minimum inhibitory concentration , bacteria , medicine , biochemistry , genetics , receptor , dermatology , biology
In this article, a new series of 2,3‐disubstituted‐1,3‐thiazolidin‐4‐one derivatives have been designed, synthesized, and evaluated as antimicrobial agents . New compounds were prepared by the cyclization reaction of N ‐substituted carboxylic acid hydrazide derivatives with mercaptoacetic acid. The structures of the obtained compounds were confirmed by means of IR, 1 H NMR, and 13 C NMR spectra. The dissociation constants were determined using spectrophotometric method. All synthesized compounds were tested for their in vitro antibacterial and antifungal activities using the broth microdilution method.