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Synthesis of Some Novel Class of Peptides from α ‐Amino Nitrones and Their Potential Biological Activities
Author(s) -
Chakraborty Bhaskar,
Samanta Amalesh,
Luitel Govinda Prasad,
Rai Neelam,
Mitra Debmalya
Publication year - 2016
Publication title -
journal of heterocyclic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.321
H-Index - 59
eISSN - 1943-5193
pISSN - 0022-152X
DOI - 10.1002/jhet.2416
Subject(s) - chemistry , yield (engineering) , combinatorial chemistry , amino acid , peptide synthesis , organic chemistry , stereochemistry , biochemistry , materials science , metallurgy
α ‐amino nitrones are found to have a great significance in the synthesis of peptides. Simple reaction methodology, high yield, and atom efficiency in these reactions have made this protocol highly attractive. The synthetic route may be extended to the synthesis of dipeptides in enantiomerically pure form. Potential biological activity of the newly synthesized peptides is the major application in this new methodology.