Premium
Chemistry of 2‐Aminoimidazoles
Author(s) -
Žula Aleš,
Kikelj Danijel,
Ilaš Janez
Publication year - 2016
Publication title -
journal of heterocyclic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.321
H-Index - 59
eISSN - 1943-5193
pISSN - 0022-152X
DOI - 10.1002/jhet.2415
Subject(s) - chemistry , moiety , natural compound , ring (chemistry) , combinatorial chemistry , block (permutation group theory) , organic chemistry , stereochemistry , biochemical engineering , geometry , mathematics , engineering
The 2‐aminoimidazole (2‐AI) ring is used widely as a building block in the design of new biologically active compounds, because of its good physico‐chemical properties and potent activity in various test systems. Many marine alkaloids contain the 2‐AI moiety. As a consequence, many synthetic routes have been developed in the total synthesis of natural compounds. The review covers all synthetic procedures for construction of 2‐AI in particular and its analogs up to December 2014.