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Synthesis and Biological Activities of Novel 6‐Alkylamino‐11,12‐dihydro‐11‐arylbenzo[ c ]phenanthridine Derivatives
Author(s) -
Zhang Min,
Liu Li,
Xiao Huifeng,
Zhao Ting,
Yang Liuqing,
Xu Xiaohua
Publication year - 2016
Publication title -
journal of heterocyclic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.321
H-Index - 59
eISSN - 1943-5193
pISSN - 0022-152X
DOI - 10.1002/jhet.2410
Subject(s) - phenanthridine , chemistry , alternaria solani , stereochemistry , proton nmr , bioassay , two dimensional nuclear magnetic resonance spectroscopy , fungicide , botany , genetics , biology
A series of novel benzo[ c ]phenanthridine derivatives 2a , 2b , 2c , 2d , 2e , 2f , 2g , 2h , 2i , 2j , 2k , 2l , 2m and 3a , 3b , 3c , 3d , 3e , 3f bearing an alkylamino side chain at their 6‐position were synthesized. All of the target compounds were confirmed by 1 H NMR, 13 C NMR, and HRMS, and some of them were also characterized by IR and 19 F NMR. The preliminary bioassays showed that the target compounds displayed fungicidal activities; for example, compound 2l showed 60.0% and 70.0% inhibitive activity against Alternaria solani and Cercospora arachidicola at 50 mg/L, respectively, and some compounds also displayed plant growth‐regulating activities.

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