Premium
Fused Heterocycles: Synthesis and Antitubercular Activity of Novel 6‐Substituted‐2‐(4‐methyl‐2‐substituted phenylthiazol‐5‐yl) H ‐imidazo[1,2‐ a ]pyridine
Author(s) -
Abhale Yogita K.,
Deshmukh Keshav K.,
Sasane Amit V.,
Chavan Abhijit P.,
Mhaske Pravin C.
Publication year - 2016
Publication title -
journal of heterocyclic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.321
H-Index - 59
eISSN - 1943-5193
pISSN - 0022-152X
DOI - 10.1002/jhet.2409
Subject(s) - chemistry , thiazole , mycobacterium smegmatis , pyridine , substituent , stereochemistry , antimycobacterial , strain (injury) , methyl group , medicinal chemistry , mycobacterium tuberculosis , organic chemistry , group (periodic table) , tuberculosis , medicine , pathology
A series of 6‐substituted‐2‐(4‐methyl‐2‐substituted phenylthiazol‐5‐yl) H ‐imidazo[1,2‐ a ]pyridine derivatives 4a , 4b , 4c , 4d , 4e , 4f , 4g , 4h , 4i , 4j , 4k , 4l is described. The antitubercular activity of the synthesized compounds was determined against Mycobacterium smegmatis MC 2 155 strain. From the activity result, it was found that the phenyl or 4‐fluorophenyl group at 2 position of thiazole nucleus and bromo substituent at 6 position of imidazo[1,2‐a]pyridine showed good antitubercular activity.