Fused Heterocycles: Synthesis and Antitubercular Activity of Novel 6‐Substituted‐2‐(4‐methyl‐2‐substituted phenylthiazol‐5‐yl) H ‐imidazo[1,2‐ a ]pyridine | Zendy

Abhale Yogita K. | Zendy; Deshmukh Keshav K. | Zendy; Sasane Amit V. | Zendy; Chavan Abhijit P. | Zendy; Mhaske Pravin C. | Zendy

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Fused Heterocycles: Synthesis and Antitubercular Activity of Novel 6‐Substituted‐2‐(4‐methyl‐2‐substituted phenylthiazol‐5‐yl) H ‐imidazo[1,2‐ a ]pyridine

Author(s) -

Abhale Yogita K.,

Deshmukh Keshav K.,

Sasane Amit V.,

Chavan Abhijit P.,

Mhaske Pravin C.

Publication year - 2016

Publication title -

journal of heterocyclic chemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.321

H-Index - 59

eISSN - 1943-5193

pISSN - 0022-152X

DOI - 10.1002/jhet.2409

Subject(s) - chemistry , thiazole , mycobacterium smegmatis , pyridine , substituent , stereochemistry , antimycobacterial , strain (injury) , methyl group , medicinal chemistry , mycobacterium tuberculosis , organic chemistry , group (periodic table) , tuberculosis , medicine , pathology

A series of 6‐substituted‐2‐(4‐methyl‐2‐substituted phenylthiazol‐5‐yl) H ‐imidazo[1,2‐ a ]pyridine derivatives 4a , 4b , 4c , 4d , 4e , 4f , 4g , 4h , 4i , 4j , 4k , 4l is described. The antitubercular activity of the synthesized compounds was determined against Mycobacterium smegmatis MC 2 155 strain. From the activity result, it was found that the phenyl or 4‐fluorophenyl group at 2 position of thiazole nucleus and bromo substituent at 6 position of imidazo[1,2‐a]pyridine showed good antitubercular activity.

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