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Synthesis of Novel Indolo‐Spirocyclic Compounds
Author(s) -
ElSayed Mardia T.,
Mahmoud Kazem,
Hilgeroth Andreas,
Fakhr Issa M. I.
Publication year - 2016
Publication title -
journal of heterocyclic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.321
H-Index - 59
eISSN - 1943-5193
pISSN - 0022-152X
DOI - 10.1002/jhet.2402
Subject(s) - chemistry , cyclohexanone , isatin , cyclohexane , electrophile , condensation , combinatorial chemistry , stereochemistry , organic chemistry , catalysis , physics , thermodynamics
In the present work, we succeeded to synthesize the novel indolo‐spirocyclic compounds ( 4 , 5 , 6 , 7 and 11 ) via electrophilic condensation reactions of indoles with carbonyl compounds including different types of ketones, for example, heteroacetyl ketones (3‐acetylindole and 3‐acetylpyridine), cyclohexanone, isatin, cyclohexane‐1,4‐dione, whereas an attempt to prepare the spirocyclic 9 failed. This new idea will open a high prospective for continuous investigations related to the synthesis of novel indolo‐spirocyclic compounds.