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A Systematic Study on the Synthesis of n ‐Butyl Substituted 8‐Aminoquinolines
Author(s) -
Koseoglu Ahmet,
Gul Turan,
Acar Ali Ersin
Publication year - 2016
Publication title -
journal of heterocyclic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.321
H-Index - 59
eISSN - 1943-5193
pISSN - 0022-152X
DOI - 10.1002/jhet.2399
Subject(s) - aminoquinolines , chemistry , quinoline , ring (chemistry) , nmr spectra database , organic chemistry , medicinal chemistry , combinatorial chemistry , spectral line , physics , astronomy
A systematic study on the synthesis of 8‐aminoquinoline derivatives with an n ‐butyl group at each alternate position of the quinoline ring was carried out. Skraup Reaction and its Doebner–von Miller variation were used to obtain most of the quinoline ring except for the 2‐butyl‐8‐aminoquinolines and 4‐butyl‐8‐aminoquinolines where the commercially available methylquinoline derivatives were used as precursors. The structures of the synthesized compounds were characterized by FTIR, 1 H‐NMR, COSY, 13 C‐NMR and HRMS spectra.