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An Easy Access to the Synthesis of Sugar‐Based N ‐Methyl‐Pyrrolidine via [3 + 2] Cycloaddition Methodology
Author(s) -
Arasasppan Hemamalini,
Thangamuthu Mohan Das
Publication year - 2016
Publication title -
journal of heterocyclic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.321
H-Index - 59
eISSN - 1943-5193
pISSN - 0022-152X
DOI - 10.1002/jhet.2398
Subject(s) - pyrrolidine , chemistry , cycloaddition , sarcosine , paraformaldehyde , sugar , azomethine ylide , elemental analysis , organic chemistry , 1,3 dipolar cycloaddition , glycine , catalysis , biochemistry , amino acid
Sugar‐based N ‐methyl‐pyrrolidine derivatives have been synthesized by the cycloaddition reaction of the ylide generated from sarcosine and paraformaldehyde with the sugar‐derived dipolarophile. All the newly synthesized products were characterized by NMR ( 1 H, 13 C), mass spectroscopy and elemental analysis.