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A Novel One‐Pot Method for the Synthesis of Pyrimidine Derivatives Using Ketene N,S‐Acetal with Aryl Aldehydes
Author(s) -
Hagimori Masayori,
Murakami Yuka,
Mizuyama Naoko,
Tominaga Yoshinori
Publication year - 2016
Publication title -
journal of heterocyclic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.321
H-Index - 59
eISSN - 1943-5193
pISSN - 0022-152X
DOI - 10.1002/jhet.2397
Subject(s) - ketene , chemistry , acetal , pyrimidine , aryl , catalysis , organic chemistry , solvent , combinatorial chemistry , stereochemistry , alkyl
A very simple and facile one‐pot method for the synthesis of pyrimidine derivatives is presented. In this method, 2‐aryl‐pyrimidine derivatives were prepared by the reaction of ketene N,S‐acetal 1 with commercially available aryl aldehydes by heating under solvent and catalyst‐free conditions. The synthesized pyrimidine derivatives showed blue‐green fluorescence in solid state.