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Synthesis of Cycloalk[ b ]indole Bearing Spiropiperidine Derivatives
Author(s) -
Hızlıateş Cevher Gündoğdu,
Gülle Sibel,
Ergün Yavuz
Publication year - 2016
Publication title -
journal of heterocyclic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.321
H-Index - 59
eISSN - 1943-5193
pISSN - 0022-152X
DOI - 10.1002/jhet.2395
Subject(s) - chemistry , indole test , moiety , stereochemistry , glutethimide , combinatorial chemistry , pharmacology , medicine
The novel heterocyclic compounds that have cycloalk[ b ]indole moiety bearing spiropiperidinone and spiropiperidinedione ( 3a , 3b , 3c , 5a , 5b , 8a , 8b , and 10a ) were synthesized for the first time. The synthesis of spiropiperidinone and spiropiperidinedione structures was performed by a new method. These compounds are similar to sedative and hypnotic drugs such as methyprylon, glutethimide, and thalidomide.