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Design, Synthesis and Evaluation of Antibacterial Effects of a New Class of Piperazinylquinolone Derivatives
Author(s) -
Darehkordi Ali,
Ramezani Mahin,
Rahmani Fariba,
Ramezani Mahnaz
Publication year - 2016
Publication title -
journal of heterocyclic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.321
H-Index - 59
eISSN - 1943-5193
pISSN - 0022-152X
DOI - 10.1002/jhet.2391
Subject(s) - chemistry , cyanuric chloride , antibacterial activity , chloride , combinatorial chemistry , organic chemistry , bacteria , genetics , biology
Pentafluoropyridine derivatives and cyanuric chloride were used for the synthesis of new piperazinylquinolone derivatives. These reactions provided N ‐fluoropyridiyl and N ‐cyanoryl chloride piperazinylquinolone derivatives in good yields. Synthesized compounds were evaluated for their antibacterial activities. These compounds displayed good to excellent antibacterial activities.