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Design and Synthesis of Novel Triazolyl Benzoxazine Derivatives and Evaluation of Their Antiproliferative and Antibacterial Activity
Author(s) -
Khan Abdullah,
Prasad Suchita,
Parmar Virinder S.,
Sharma Sunil K.
Publication year - 2016
Publication title -
journal of heterocyclic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.321
H-Index - 59
eISSN - 1943-5193
pISSN - 0022-152X
DOI - 10.1002/jhet.2387
Subject(s) - chemistry , hela , bacillus subtilis , antibacterial activity , cycloaddition , pseudomonas aeruginosa , combinatorial chemistry , pyrazine , ovarian cancer , bacteria , stereochemistry , cell , catalysis , biochemistry , cancer , genetics , biology , medicine
A series of novel triazolyl benzoxazine derivatives have been synthesized via Cu(I)‐catalyzed ‘Click’ cycloaddition . All of the compounds were fully characterized from their spectral data, and their antiproliferative activity was evaluated against three selected human cancer cell lines: cervical cancer cells (HeLa), colorectal adenocarcinoma (HT‐29), and ovarian adenocarcinoma (SKOV‐3). A few representative compounds have also been evaluated for their antibacterial potential against two bacterial strains Pseudomonas aeruginosa and Bacillus subtilis .