Design and Synthesis of Novel Triazolyl Benzoxazine Derivatives and Evaluation of Their Antiproliferative and  Antibacterial Activity | Zendy

Khan Abdullah | Zendy; Prasad Suchita | Zendy; Parmar Virinder S. | Zendy; Sharma Sunil K. | Zendy

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Design and Synthesis of Novel Triazolyl Benzoxazine Derivatives and Evaluation of Their Antiproliferative and Antibacterial Activity

Author(s) -

Khan Abdullah,

Prasad Suchita,

Parmar Virinder S.,

Sharma Sunil K.

Publication year - 2016

Publication title -

journal of heterocyclic chemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.321

H-Index - 59

eISSN - 1943-5193

pISSN - 0022-152X

DOI - 10.1002/jhet.2387

Subject(s) - chemistry , hela , bacillus subtilis , antibacterial activity , cycloaddition , pseudomonas aeruginosa , combinatorial chemistry , pyrazine , ovarian cancer , bacteria , stereochemistry , cell , catalysis , biochemistry , cancer , genetics , biology , medicine

A series of novel triazolyl benzoxazine derivatives have been synthesized via Cu(I)‐catalyzed ‘Click’ cycloaddition . All of the compounds were fully characterized from their spectral data, and their antiproliferative activity was evaluated against three selected human cancer cell lines: cervical cancer cells (HeLa), colorectal adenocarcinoma (HT‐29), and ovarian adenocarcinoma (SKOV‐3). A few representative compounds have also been evaluated for their antibacterial potential against two bacterial strains Pseudomonas aeruginosa and Bacillus subtilis .

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