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An efficient method to prepare 4‐aminoquinazolines: Potential application to conformation‐restricted bleomycin analogs
Author(s) -
Wei Zhonglin,
Zheng Lianyou,
Dang Qun,
Bai Xu
Publication year - 2009
Publication title -
journal of heterocyclic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.321
H-Index - 59
eISSN - 1943-5193
pISSN - 0022-152X
DOI - 10.1002/jhet.238
Subject(s) - chemistry , bleomycin , combinatorial chemistry , chelation , stereochemistry , nanotechnology , organic chemistry , medicine , surgery , chemotherapy , materials science
To enhance the iron‐chelating ability of P‐3A, 4‐aminoquinazolines were designed as conformation‐restricted bleomycin analogs. An efficient method was developed to prepare the 4‐aminoquinazoline heterocyclic nucleus, which entails a two‐step one‐pot procedure leading to 4‐aminoquinazolines in good yields. The application of this method to synthesis 4‐aminoquinazoline bleomycin analogs is envisioned. J. Heterocyclic Chem., (2009).