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Synthesis and Antimicrobial Activity of Some Novel Hydrazide, Pyrazole, Triazine, Isoxazole, and Pyrimidine Derivatives
Author(s) -
Refat Hala M.,
Fadda A. A.
Publication year - 2016
Publication title -
journal of heterocyclic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.321
H-Index - 59
eISSN - 1943-5193
pISSN - 0022-152X
DOI - 10.1002/jhet.2369
Subject(s) - chemistry , isoxazole , hydrazide , antimicrobial , moiety , pyrazole , triazine , pyrimidine , methylene , reagent , proton nmr , combinatorial chemistry , organic chemistry , medicinal chemistry , stereochemistry
In continuation of our efforts to find a new class of antimicrobial agents , a series of pyrazole, 1,2,4‐triazine, isoxazole, pyrimidine, and other related products containing a hydrazide moiety were prepared via the reaction of 2‐cyano‐ N ‐((2‐methoxynaphthalen‐1‐yl)methylene) acetohydrazide ( 1 ) with appropriate chemical reagents. These compounds were evaluated for their antimicrobial activities, and also their minimum inhibitory concentration against most of test organisms was performed. Among the tested compounds 4 , 5 , 6 , and 16 displayed excellent antimicrobial activity . All the synthesized products were confirmed by elemental analysis, IR, 1 H‐NMR, 13 C‐NMR, and mass spectral data.