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Synthesis of New Triazole and Oxadiazole Derivatives of Quinazolin‐4(3 H )‐one and Their Antimicrobial Activity
Author(s) -
Veena Vani Kotla,
Ramesh Garlapati,
Venkata Rao Chunduri
Publication year - 2016
Publication title -
journal of heterocyclic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.321
H-Index - 59
eISSN - 1943-5193
pISSN - 0022-152X
DOI - 10.1002/jhet.2353
Subject(s) - chemistry , oxadiazole , bacillus subtilis , aspergillus niger , antimicrobial , candida albicans , triazole , pseudomonas aeruginosa , staphylococcus aureus , 1,2,4 triazole , antibacterial activity , escherichia coli , bacteria , proton nmr , combinatorial chemistry , stereochemistry , organic chemistry , microbiology and biotechnology , biochemistry , biology , genetics , gene
A series of new triazole derivatives of quinazolin‐4(3 H )‐one and new oxadiazole derivatives of quinazolin‐4(3 H )‐one were synthesized. The newly synthesized compounds were characterized by IR, 1 H NMR, 13 C NMR and mass spectral data. All the newly synthesized compounds were screened for antibacterial activity against Staphylococcus aureus , Bacillus subtilis (gram‐positive bacteria), Escherichia coli , Pseudomonas aeruginosa (gram‐negative bacteria), and antifungal activity was carried out against Candida albicans and Aspergillus niger .
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