Synthesis of Novel 1 H ‐Imidazol[1,2‐a]Indeno[2,1‐e]Pyridine‐6(5 H )‐Ones Derivatives via a One‐Pot Four‐Component  Condensation Reaction | Zendy

Mohammadi Ali A. | Zendy; Taheri Salman | Zendy; Amouzegar Ali | Zendy

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Synthesis of Novel 1 H ‐Imidazol[1,2‐a]Indeno[2,1‐e]Pyridine‐6(5 H )‐Ones Derivatives via a One‐Pot Four‐Component Condensation Reaction

Author(s) -

Mohammadi Ali A.,

Taheri Salman,

Amouzegar Ali

Publication year - 2016

Publication title -

journal of heterocyclic chemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.321

H-Index - 59

eISSN - 1943-5193

pISSN - 0022-152X

DOI - 10.1002/jhet.2352

Subject(s) - chemistry , ketene , pyridine , condensation , catalysis , component (thermodynamics) , combinatorial chemistry , diamine , organic chemistry , nitro , condensation reaction , medicinal chemistry , physics , thermodynamics , alkyl

1 H ‐imidazol[1,2‐a]indeno[2,1‐e]pyridine‐6(5 H )‐ones derivatives were synthesized in a one‐pot four‐component condensation of corresponding aldehydes, 1,3‐indandione, diamine, and nitro ketene dithioacetal using KAl(SO 4 ) 2 ·12H 2 O (alum) as nontoxic, reusable, inexpensive and easily available catalyst in good to excellent yields. This green protocol provides a powerful entry into fused polycyclic structures related to bioactive heterocycles.

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