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Synthesis of Novel 1 H ‐Imidazol[1,2‐a]Indeno[2,1‐e]Pyridine‐6(5 H )‐Ones Derivatives via a One‐Pot Four‐Component Condensation Reaction
Author(s) -
Mohammadi Ali A.,
Taheri Salman,
Amouzegar Ali
Publication year - 2016
Publication title -
journal of heterocyclic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.321
H-Index - 59
eISSN - 1943-5193
pISSN - 0022-152X
DOI - 10.1002/jhet.2352
Subject(s) - chemistry , ketene , pyridine , condensation , catalysis , component (thermodynamics) , combinatorial chemistry , diamine , organic chemistry , nitro , condensation reaction , medicinal chemistry , physics , thermodynamics , alkyl
1 H ‐imidazol[1,2‐a]indeno[2,1‐e]pyridine‐6(5 H )‐ones derivatives were synthesized in a one‐pot four‐component condensation of corresponding aldehydes, 1,3‐indandione, diamine, and nitro ketene dithioacetal using KAl(SO 4 ) 2 ·12H 2 O (alum) as nontoxic, reusable, inexpensive and easily available catalyst in good to excellent yields. This green protocol provides a powerful entry into fused polycyclic structures related to bioactive heterocycles.