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An efficient one‐pot synthesis of some new 2,4‐diaryl pyrido[3,2‐c]coumarins as potent antimicrobial agents
Author(s) -
Dawane Bhaskar S.,
Konda Shankaraiah G.,
Bodade Ragini G.,
Bhosale Raghunath B.
Publication year - 2010
Publication title -
journal of heterocyclic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.321
H-Index - 59
eISSN - 1943-5193
pISSN - 0022-152X
DOI - 10.1002/jhet.234
Subject(s) - chemistry , coumarin , antimicrobial , ammonium acetate , antifungal , ethylene glycol , organic chemistry , solvent , combinatorial chemistry , ammonium , high performance liquid chromatography , microbiology and biotechnology , biology
Poly(ethylene glycol) (PEG‐400) has been used as sustainable, nonvolatile, and environmental friendly reaction solvent for the synthesis of title compounds. Various diaryl pyrido[3,2‐c]coumarins have been synthesized in one step by reacting 4‐hydroxy‐7‐methyl‐coumarin with α,β‐unsaturated ketones in the presence of ammonium acetate. Further, in vitro antimicrobial (antibacterial and antifungal) activities of the compounds were screened against different pathogens. The results revealed that most of them showed potent activity. J. Heterocyclic Chem., (2010).