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Microwave Energized Synthesis of 2‐Aroylindole Derivatives: Piperidine/DMF as an Effective Medium
Author(s) -
Soora Haranath Jayaprakash,
Balam Satheesh Krishna,
Chereddy Syama Sundar,
Sthanikam Siva Prasad,
Sarva Santhisudha,
Gundluru Mohan,
Cirandur Suresh Reddy
Publication year - 2016
Publication title -
journal of heterocyclic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.321
H-Index - 59
eISSN - 1943-5193
pISSN - 0022-152X
DOI - 10.1002/jhet.2334
Subject(s) - chemistry , piperidine , microwave irradiation , phenacyl , microwave , combinatorial chemistry , reaction conditions , organic chemistry , catalysis , physics , quantum mechanics
A convenient and efficient protocol has been developed for the synthesis of 2‐aroylindoles ( 3a , 3b , 3c , 3d , 3e , 3f , 3g , 3h , 3i , 3j ) in good yields by the reaction of 2‐aminoketones ( 1a , 1b , 1c ) with phenacyl bromides ( 2a , 2b , 2c , 2d ). The reaction success varied with different bases and solvents in both conventional and microwave methods. But finally, it was established that piperidine in DMF was an effective medium to carry out the reaction under microwave irradiation conditions.