Csp 2 –O and C–C Bond Formation via Pd‐Catalyzed  Coupling Reaction  of 2,4‐Dichloroquinazoline | Zendy

Sharma Alka | Zendy; Luxami Vijay | Zendy; Paul Kamaldeep | Zendy

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Csp 2 –O and C–C Bond Formation via Pd‐Catalyzed Coupling Reaction of 2,4‐Dichloroquinazoline

Author(s) -

Sharma Alka,

Luxami Vijay,

Paul Kamaldeep

Publication year - 2016

Publication title -

journal of heterocyclic chemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.321

H-Index - 59

eISSN - 1943-5193

pISSN - 0022-152X

DOI - 10.1002/jhet.2330

Subject(s) - chemistry , aryl , catalysis , palladium , combinatorial chemistry , halide , ketone , transformation (genetics) , medicinal chemistry , organic chemistry , biochemistry , alkyl , gene

An efficient palladium‐catalyzed C–O and subsequent C–C bond formation of 2,4‐dichloroquinazoline have been described. The designed strategy results in the synthesis of novel 2‐arylated quinazolin‐4‐ones framework with various aryl/heteroaryl boronic acids in moderate to good yields along with 2,4‐diarylated quinazolines. This methodology offers a direct transformation of aryl halides to aryl alcohols/ketone as well as the straight forward application to generate a wide variety of monoaryl and diaryl quinazoline.

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