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Synthesis of Novel Heterocycles Derived from 4‐Arylmethylene‐2‐phenyl‐1,3‐oxazole‐5(4 H )‐ones
Author(s) -
Youssef Ahmed S. A.,
Kandeel Kamal A.,
AbouElmagd Wael S. I.,
Haneen David S. A.
Publication year - 2016
Publication title -
journal of heterocyclic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.321
H-Index - 59
eISSN - 1943-5193
pISSN - 0022-152X
DOI - 10.1002/jhet.2329
Subject(s) - chemistry , pyrazolone , malononitrile , oxazole , thioglycolic acid , carbon 13 nmr , hydrazide , pyrazolones , antimicrobial , proton nmr , organic chemistry , derivative (finance) , combinatorial chemistry , catalysis , financial economics , economics
The acid hydrazide derivatives 2 were converted into pyrazolone, triazinone, and schiff bases. However, the reaction of Schiff base 12 with malononitrile or thioglycolic acid gives the pyrazolotriazinone or thiazolidinone derivative, respectively. The structures of the newly synthesized compounds were established on the basis of IR, 1 H‐NMR, mass spectral data, and elemental analyses. The antimicrobial activities of the synthesized compounds were examined against two types of bacteria and two types of fungi. Some of the tested compounds showed promising activities.