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Ultrasound Assisted Synthesis of Some Novel Bis‐Pyridazine Derivatives
Author(s) -
Mekky Ahmed E. M.,
AlBogami Abdullah S.
Publication year - 2016
Publication title -
journal of heterocyclic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.321
H-Index - 59
eISSN - 1943-5193
pISSN - 0022-152X
DOI - 10.1002/jhet.2328
Subject(s) - chemistry , pyridazine , ultrasound , ultrasonic sensor , combinatorial chemistry , irradiation , organic chemistry , physics , nuclear physics , acoustics
Bis‐enaminone 3 was coupled with aryldiazonium chlorides 4a , 4b to afford the bis‐arylhydrazonopropanals 6a , 6b . Compounds 6a , 6b could be utilized for the synthesis of a variety of bis‐(dimethyl 2,3‐dihydropyridazine‐3,4‐dicarboxylate), bis‐(pyridazin‐3( 2H )‐one), bis‐(2,3‐dihydropyridazine‐4‐carbonitrile) and bis‐(3‐imino‐2,3‐dihydropyridazine) derivatives, under ultrasonic irradiation. A comparative study of aforementioned reactions was carried out under conventional method as well as under ultrasonic irradiation conditions.