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Application of Pfitzinger Reaction to the Facile One‐Pot Access of the Novel (5,6‐b)‐Quinolino‐8‐carboxylic‐acid‐Annulated Analogs of (2,3‐d)‐Azepino‐benzimidazol‐2,6‐diones of Medicinal Interest
Author(s) -
Garg Neha,
Jain Priyanka,
Kishore D.
Publication year - 2016
Publication title -
journal of heterocyclic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.321
H-Index - 59
eISSN - 1943-5193
pISSN - 0022-152X
DOI - 10.1002/jhet.2325
Subject(s) - chemistry , combinatorial chemistry , carboxylic acid , reaction conditions , stereochemistry , computational chemistry , medicinal chemistry , organic chemistry , catalysis
The potential of the Pfitzinger reaction has been explored to provide an expedient protocol to the synthesis of novel (5,6‐b)‐quinolino‐8‐carboxylic acid annulated analogues of (2,3‐d)‐azepino benzimidazol‐2,6‐diones 6a , 6b , 6c , 6d , 6e , 6f , 6g from (2,3‐d)‐azepino‐benzimidazol‐2,6,9‐triones 4 and isatins 5a , 5b , 5c , 5d , 5e , 5f , 5g .