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New One Pot‐synthesis of Functionally Substituted Pyridines from Enaminoketones
Author(s) -
ElTaweel Fathy,
Abou Elmaaty Tarek
Publication year - 2015
Publication title -
journal of heterocyclic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.321
H-Index - 59
eISSN - 1943-5193
pISSN - 0022-152X
DOI - 10.1002/jhet.2291
Subject(s) - chemistry , pyridine , reagent , condensation , condensation reaction , medicinal chemistry , organic chemistry , combinatorial chemistry , catalysis , physics , thermodynamics
Several new pyridine derivatives were prepared via reaction of enaminoketones 1a , 1b , 1c , 1d with active hydrogen reagents. Reaction of the enaminoketones 1a , 1b , 1c with 4‐acetyl‐1,5‐dimethyl‐2‐phenyl‐1 H ‐pyrazol‐3(2 H )‐one 2a yielded the pyridines 3a , 3b , 3c . Condensation of the enaminonitrile 1d with compounds 2b , 2c , 2d and compound 8 gave the pyridine derivatives 6a , 6b , 6c and 10 respectively. Also, (3‐(dimethylamino)acryloyl)‐2 H ‐chromen‐2‐one 1a reacted with active methylenes in diethyl 3‐oxopentanedioate 12 and 4‐methyl‐6‐oxo‐2‐thioxo‐1,2,5,6‐tetrahydropyridine‐3‐carbonitrile 15 to afford the pyridine derivatives 14 and 16 respectively.