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A simple and practical method for the synthesis of 2‐amino‐5,6‐dihydro‐5,7‐diarylquinazolin‐4‐ols
Author(s) -
Senguttuvan S.,
Nagarajan Samuthira
Publication year - 2009
Publication title -
journal of heterocyclic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.321
H-Index - 59
eISSN - 1943-5193
pISSN - 0022-152X
DOI - 10.1002/jhet.229
Subject(s) - chemistry , guanidine , yield (engineering) , hydrochloride , simple (philosophy) , proton nmr , organic chemistry , combinatorial chemistry , philosophy , materials science , epistemology , metallurgy
We report an efficient and new method of synthesis of 2‐amino‐5,6‐dihydro‐5,7‐diarylquinazolin‐4‐ols by the reaction of substituted cyclohexenones with guanidine hydrochloride in presence of NaOEt. The reactions are with 50–72% yield. All the synthesized compounds are characterized using IR, NMR and CHN analysis. J. Heterocyclic Chem., (2009).