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4‐Hydroxy‐1‐phenylquinolin‐2(1 H )‐one in One‐pot Synthesis of Pyrimidoquinolines and Related Compounds under Microwave Irradiation and Conventional Conditions
Author(s) -
Mourad AboulFetouh E.,
Amer Amer A.,
ElShaieb Kamal M.,
Ali Ali M.,
Aly Ashraf A.
Publication year - 2016
Publication title -
journal of heterocyclic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.321
H-Index - 59
eISSN - 1943-5193
pISSN - 0022-152X
DOI - 10.1002/jhet.2286
Subject(s) - chemistry , thiourea , microwave irradiation , benzimidazole , condensation , urea , one pot synthesis , aryl , amine gas treating , medicinal chemistry , microwave , organic chemistry , catalysis , physics , alkyl , quantum mechanics , thermodynamics
Biginelli condensation reactions of 4‐hydroxy‐1‐phenylquinolin‐2(1 H )‐one, aryl aldehydes and urea, or thiourea, 5‐amino‐1 H ‐1,2,4‐triazole, or 2‐amine‐1 H ‐benzimidazole ( 9 ) under microwave irradiation afforded the corresponding pyrimido[5,4‐ c ]quinolin‐5‐one derivatives in high yields. One‐pot synthesis of 2H ‐pyrano[3,2‐ c ]quinolines is also reported.