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Catalyst‐Free and Green Synthesis of Some Novel Benzamide Derivatives
Author(s) -
Samani Ghaleh Taki Banafshe,
Rostami Mahbubeh,
Mirkhani Valiollah,
Moghadam Majid,
MohammadpoorBaltork Iraj,
Tangestaninejad Shahram,
Jamali Moghadam Ahmad,
Kia Reza
Publication year - 2015
Publication title -
journal of heterocyclic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.321
H-Index - 59
eISSN - 1943-5193
pISSN - 0022-152X
DOI - 10.1002/jhet.2275
Subject(s) - benzamide , chemistry , catalysis , ethylene diamine , ethylene , reaction conditions , combinatorial chemistry , work (physics) , organic chemistry , ring (chemistry) , solvent , nuclear chemistry , thermodynamics , physics
In the present work, a simple, green, rapid, and catalyst‐free procedure for the synthesis of benzamide derivatives by ring opening of azlactones with diamines such as ethylene diamine and 1,3‐propylenediamine is described. The present method offers several advantages such as short reaction times, easy work‐up, and mild reaction conditions in the absence of catalyst and any toxic solvent and material. In addition, the structure obtained by X‐ray crystallography was compared with the theoretical results obtained by density functional theory using the B3LYP functional and cc‐pVDZ basis sets.