z-logo
Premium
Synthesis and In Vitro Cytotoxic Activity of Novel Triazole‐Isoxazole Derivatives
Author(s) -
Najafi Zahra,
Mahdavi Mohammad,
Safavi Maliheh,
Saeedi Mina,
Alinezhad Heshmatollah,
Pordeli Mahboobeh,
Kabudanian Ardestani Sussan,
Shafiee Abbas,
Foroumadi Alireza,
Akbarzadeh Tahmineh
Publication year - 2015
Publication title -
journal of heterocyclic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.321
H-Index - 59
eISSN - 1943-5193
pISSN - 0022-152X
DOI - 10.1002/jhet.2273
Subject(s) - isoxazole , chemistry , cytotoxic t cell , in vitro , triazole , mtt assay , 1,2,3 triazole , aryl , combinatorial chemistry , cytotoxicity , stereochemistry , organic chemistry , biochemistry , alkyl
New derivatives of triazole‐isoxazole were synthesized through a four‐step reaction starting from various ethyl 4‐aryl‐2,4‐dioxobutanoate derivatives. Finally, all compounds were examined by MTT assays for cytotoxic activity in two human breast cancer cell lines (MCF‐7 and T‐47D).

This content is not available in your region!

Continue researching here.

Having issues? You can contact us here