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Synthesis and In Vitro Cytotoxic Activity of Novel Triazole‐Isoxazole Derivatives
Author(s) -
Najafi Zahra,
Mahdavi Mohammad,
Safavi Maliheh,
Saeedi Mina,
Alinezhad Heshmatollah,
Pordeli Mahboobeh,
Kabudanian Ardestani Sussan,
Shafiee Abbas,
Foroumadi Alireza,
Akbarzadeh Tahmineh
Publication year - 2015
Publication title -
journal of heterocyclic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.321
H-Index - 59
eISSN - 1943-5193
pISSN - 0022-152X
DOI - 10.1002/jhet.2273
Subject(s) - isoxazole , chemistry , cytotoxic t cell , in vitro , triazole , mtt assay , 1,2,3 triazole , aryl , combinatorial chemistry , cytotoxicity , stereochemistry , organic chemistry , biochemistry , alkyl
New derivatives of triazole‐isoxazole were synthesized through a four‐step reaction starting from various ethyl 4‐aryl‐2,4‐dioxobutanoate derivatives. Finally, all compounds were examined by MTT assays for cytotoxic activity in two human breast cancer cell lines (MCF‐7 and T‐47D).