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Synthesis of Some Novel 3‐Substituted Indole Derivatives Using Polyamine Functionalized Heterogeneous Catalyst
Author(s) -
Magar Rupali L.,
Thorat Prashant B.,
Waware Jagdish L.,
More Rameshwar R.,
Solanke Usha A.,
Patil Bhagwan R.,
Pawar Rajendra P.
Publication year - 2015
Publication title -
journal of heterocyclic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.321
H-Index - 59
eISSN - 1943-5193
pISSN - 0022-152X
DOI - 10.1002/jhet.2265
Subject(s) - knoevenagel condensation , chemistry , indole test , catalysis , yield (engineering) , combinatorial chemistry , polyamine , organic chemistry , condensation , biochemistry , materials science , physics , metallurgy , thermodynamics
In present work, we have described the use of polyamine solid supported GN3 as catalyst in organic transformations using 1 H ‐indole‐3‐carbaldehyde. To the best of our knowledge, reports for the synthesis of chromen substituted at 3C position of indole are extremely rare in the literature. The polyamine functionalized immobilized silica (GN3) was found to be an excellent catalyst for synthesis of novel 2‐amino‐4‐(1 H ‐indol‐3‐yl)‐5‐oxo‐4,5‐dihydropyrano[3,2‐ c ]chromene‐3‐carbonitrile derivatives and Knoevenagel condensation . Catalyst GN3 was able to furnish excellent yield for a wide range of products. Moreover, the catalyst was reusable and reused for several times without loss of its catalytic activity .