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Synthesis, Crystal Structure, and Antibacterial Activity of 1,2,4‐Triazoles and 1,2,4‐Triazol‐3‐one
Author(s) -
Ben Salah Bochra,
Chaari Najla,
Rekik Awatef,
Ben Hsouna Anis,
Trigui Mohamed,
Kossentini Mohamed
Publication year - 2015
Publication title -
journal of heterocyclic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.321
H-Index - 59
eISSN - 1943-5193
pISSN - 0022-152X
DOI - 10.1002/jhet.2264
Subject(s) - chemistry , hydrazine (antidepressant) , antibacterial activity , elemental analysis , crystal structure , mass spectrometry , high resolution , combinatorial chemistry , carbon 13 nmr , mass spectrum , stereochemistry , organic chemistry , bacteria , chromatography , genetics , biology , remote sensing , geology
A straightforward method has been developed for the synthesis of 1,2,4‐triazol‐3‐one 3 and 1,2,4‐triazoles 6a , 6b , 6c , 6d starting from N 1 ‐substituted‐ N 1 ‐tosylhydrazonates 2 and hydrazine monohydrate. This methodology affords a number of 1,2,4‐triazol‐3‐one 3 and 1,2,4‐triazoles 6a , 6b , 6c , 6d in reasonable yields. The structures of all new compounds were elucidated using infrared, 1 H and 13 C NMR, high‐resolution mass spectrometry , elemental analysis, and the X‐ray crystallography (for compounds 3 and 6a ). Some of the newly synthesized compounds were screened for their antibacterial activity .