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Synthesis, Characterization, and Antibacterial Activity of Some Novel Substituted Imidazole Derivatives via One‐pot Three‐Component
Author(s) -
Ramagiri Raj Kumar,
Thupurani Murali Krishna,
Vedula Rajeswar Rao
Publication year - 2015
Publication title -
journal of heterocyclic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.321
H-Index - 59
eISSN - 1943-5193
pISSN - 0022-152X
DOI - 10.1002/jhet.2261
Subject(s) - chemistry , imidazole , phenacyl , ammonium thiocyanate , aniline , ammonium acetate , antibacterial activity , acetic acid , phenacyl bromide , organic chemistry , combinatorial chemistry , component (thermodynamics) , solvent , bacteria , high performance liquid chromatography , biology , genetics , physics , thermodynamics
A simple and highly efficient one‐pot, three‐component synthesis of novel substituted imidazole derivatives has been reported by the reaction of 3‐(2‐bromoacetyl)‐2 H ‐chromen‐2‐one, ammonium thiocyanate, and phenacyl aniline in the presence of acetic acid as a solvent under reflux condition with good yields. The structures of newly synthesized compounds were characterized by their analytical and spectral data. One of these compounds 4a showed good antibacterial activity against Escherichia coli gram‐negative strains.