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Novel and Efficient Synthesis of DHPMs Catalyzed by di‐DACH‐Pyridylamide Ligands
Author(s) -
Song Qingbao,
An Xiaoxia,
Che Fengfeng,
Shen Tianhua
Publication year - 2015
Publication title -
journal of heterocyclic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.321
H-Index - 59
eISSN - 1943-5193
pISSN - 0022-152X
DOI - 10.1002/jhet.2259
Subject(s) - chemistry , biginelli reaction , catalysis , combinatorial chemistry , base (topology) , reaction conditions , organic chemistry , mathematical analysis , mathematics
Di‐DACH‐pyridylamide ligands, symmetrical bridged bis‐Schiff base, and spiro pyrrolizines as catalysts in the synthesis of dihydropyrimidinethiones (DHPMs) using the Biginelli reaction is first reported. This new protocol has the advantages of environmental friendliness, short reaction time, excellent yields, and simple post‐treatment procedure. A series of DHPMs were obtained in high yields (up to 98%) in only 6 h. Moreover, based on the optimized condition, a novel Biginelli‐like reaction was first developed.