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Synthesis, Dissociation Constants, and Some Pharmacological Properties of Schiff Base Hydrazones and their Cyclization to 1,3‐Thiazolidin‐4‐one Derivatives
Author(s) -
Popiołek Ł.,
Chodkowska A.,
Tryka A.,
Pawłowski K.,
Kiełczykowska M.,
Kocot J.,
Wujec M.,
JagiełłoWójtowicz E.
Publication year - 2015
Publication title -
journal of heterocyclic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.321
H-Index - 59
eISSN - 1943-5193
pISSN - 0022-152X
DOI - 10.1002/jhet.2257
Subject(s) - chemistry , schiff base , dissociation constant , dissociation (chemistry) , condensation reaction , hydrazone , proton nmr , triazole , combinatorial chemistry , medicinal chemistry , organic chemistry , polymer chemistry , catalysis , biochemistry , receptor
This study presents the synthesis, dissociation constants, and pharmacological properties of Schiff base hydrazones. The derivatives were synthesized by the condensation reaction of carboxylic acid hydrazides containing 1,2,4‐triazole system with various aldehydes. The new derivatives of 1,3‐thiazolidin‐4‐one were prepared by the cyclization reaction of Schiff base hydrazones with the mercaptoacetic acid in the presence of 1,4‐dioxane. The structure of all obtained compounds was confirmed by means of 1 H NMR and 13 C NMR spectra. The dissociation constants were determined using spectrophotometric method. The effects of four synthesized Schiff base hydrazones 6 , 7 , 11 and 12 on the central nervous system of mice in behavioral tests were examined.