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A Facile Synthesis of 5‐Phenyl‐Dibenzo[ b , g ][1,8]Napthyridines
Author(s) -
Sampathkumar Natarajan,
Murugesh Arumugam,
Rajendran Subramaniam Parameswaran
Publication year - 2016
Publication title -
journal of heterocyclic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.321
H-Index - 59
eISSN - 1943-5193
pISSN - 0022-152X
DOI - 10.1002/jhet.2256
Subject(s) - chemistry , acetanilide , quinoline , yield (engineering) , aryl , medicinal chemistry , combinatorial chemistry , stereochemistry , organic chemistry , alkyl , materials science , metallurgy
The Vilsmeier Haack heterocyclization of 2‐aryl amino‐4‐phenyl quinolines quinoline yielded the hitherto unknown 5‐phenyl‐dibenzo[ b , g ][1,8]naphthyridines in quantitative yield. The synthesis of aryl amines was achieved by the action of anilines on 2‐chloro‐4‐phenyl quinoline, which in turn was sourced through the combes reaction of benzoyl acetanilides.