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Clean synthesis of furo[3,4‐ e ]pyrazolo[3,4‐ b ]pyridine‐5‐one derivatives in aqueous media
Author(s) -
Shi DaQing,
Yao Hao
Publication year - 2009
Publication title -
journal of heterocyclic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.321
H-Index - 59
eISSN - 1943-5193
pISSN - 0022-152X
DOI - 10.1002/jhet.224
Subject(s) - chemistry , pyridine , aldehyde , aqueous medium , aqueous solution , pyrazole , chloride , aryl , medicinal chemistry , organic chemistry , catalysis , alkyl
A series of 4‐aryl‐3‐methyl‐1‐phenyl‐7 H ‐furo[3,4‐ e ]pyrazolo[3,4‐ b ]pyridine‐5‐ones were synthesized via the three‐component reaction of an aldehyde, 5‐amino‐3‐methyl‐1‐phenyl‐1 H ‐pyrazole and tetronic acid in aqueous media in the presence of triethylbenzylammonium chloride (TEBAC). This method has the advantages of easier work‐up, mild reaction conditions, high yields, and an environmentally benign procedure. J. Heterocyclic Chem., (2009).