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A Multicomponent, Catalyst‐free, One‐Pot Synthesis of Functionalized 1,4‐Dihydroquinolines and Their Antimicrobial Studies
Author(s) -
Chidurala Praveen,
Jetti Venkateshwarlu,
Pagadala Ramakanth,
Meshram Jyotsna S.,
Jonnalagadda Sreekantha B.
Publication year - 2015
Publication title -
journal of heterocyclic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.321
H-Index - 59
eISSN - 1943-5193
pISSN - 0022-152X
DOI - 10.1002/jhet.2230
Subject(s) - chemistry , ammonium acetate , resorcinol , catalysis , yield (engineering) , aldehyde , microwave irradiation , antimicrobial , organic chemistry , environmentally friendly , antifungal , combinatorial chemistry , medicine , ecology , materials science , high performance liquid chromatography , dermatology , metallurgy , biology
An atom‐efficient, catalyst‐free, and environmentally friendly approach towards the synthesis of substituted 1,4‐dihydroquinolines ( 5a , 5b , 5c , 5d , 5e , 5f , 5g , 5h , 5i , 5j ) through a one‐pot multicomponent reaction involving resorcinol, aromatic aldehyde, acetoacetanilide, and ammonium acetate has been developed. The reactions were carried out under both conventional and microwave irradiation conditions. In general, improvement in rate and yield were observed when reactions were carried out under microwave irradiation compared with classical conditions. Most of the new compounds possessed moderate to significant antibacterial and antifungal activities.