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Synthesis and Biological Activity of Some Novel Aryl‐Substituted 1,3,4‐Oxadiazole Mannich Bases Containing Pyrimidine Rings
Author(s) -
Shen Shengqiang,
Sun Xiaohong,
Liu Yuanfa,
Chen Bang,
Jin Ruyi,
Ma Haixia
Publication year - 2015
Publication title -
journal of heterocyclic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.321
H-Index - 59
eISSN - 1943-5193
pISSN - 0022-152X
DOI - 10.1002/jhet.2224
Subject(s) - chemistry , pyrimidine , aryl , oxadiazole , antifungal , ring (chemistry) , mannich base , mannich reaction , proton nmr , biological activity , stereochemistry , organic chemistry , medicinal chemistry , in vitro , catalysis , biochemistry , alkyl , medicine , dermatology
A series of novel Mannich base derivatives (E 1 –E 15 ) of 5‐aryl‐1,3,4‐oxadiazole‐2‐thione with substituted pyrimidine were synthesized and characterized by elemental analysis, IR, 1 H‐NMR. The antifungal activities of these compounds were also originally studied. The results showed that most of the title compounds exhibited relatively good fungicidal activities. Especially compounds E 8 and E 13 showed better antifungal activity than comparison compound hymexazol. The relationship of structure and activity revealed that the presence of the methyl group at four and six positions of pyrimidine ring remarkably enhanced the antifungal activity of title compounds.