An Alternate Synthesis of  6H ‐Indolo[2,3‐ b ]quinoline via One‐Pot Alkylation–Dehydration–Cyclization–Aromatization Approach | Zendy

Kadam Hari K. | Zendy; Tilve Santosh G. | Zendy

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An Alternate Synthesis of 6H ‐Indolo[2,3‐ b ]quinoline via One‐Pot Alkylation–Dehydration–Cyclization–Aromatization Approach

Author(s) -

Kadam Hari K.,

Tilve Santosh G.

Publication year - 2016

Publication title -

journal of heterocyclic chemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.321

H-Index - 59

eISSN - 1943-5193

pISSN - 0022-152X

DOI - 10.1002/jhet.2213

Subject(s) - chemistry , aromatization , quinoline , alkylation , dehydration , alkaloid , organic chemistry , dehydration reaction , total synthesis , catalysis , biochemistry

A simple, straightforward and efficient synthesis of 6 H ‐indolo[2,3‐ b ]quinoline, a natural product isolated from leaves of Justicia betonica , is achieved through a pivalic acid‐assisted one‐pot alkylation–dehydration–cyclization–aromatization approach. This synthesis constitutes a formal approach toward a biologically important alkaloid neocryptolepine.

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