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An Alternate Synthesis of 6H ‐Indolo[2,3‐ b ]quinoline via One‐Pot Alkylation–Dehydration–Cyclization–Aromatization Approach
Author(s) -
Kadam Hari K.,
Tilve Santosh G.
Publication year - 2016
Publication title -
journal of heterocyclic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.321
H-Index - 59
eISSN - 1943-5193
pISSN - 0022-152X
DOI - 10.1002/jhet.2213
Subject(s) - chemistry , aromatization , quinoline , alkylation , dehydration , alkaloid , organic chemistry , dehydration reaction , total synthesis , catalysis , biochemistry
A simple, straightforward and efficient synthesis of 6 H ‐indolo[2,3‐ b ]quinoline, a natural product isolated from leaves of Justicia betonica , is achieved through a pivalic acid‐assisted one‐pot alkylation–dehydration–cyclization–aromatization approach. This synthesis constitutes a formal approach toward a biologically important alkaloid neocryptolepine.