Premium
A Facile and Efficient Approach to Seven‐membered Heterocycles by Chlorosilane‐catalyzed Domino Reaction
Author(s) -
Wang Min,
Wang Lingtian,
Guo Qin,
Ge Junjun,
Lin Deqing,
Ye Xiaoxia
Publication year - 2015
Publication title -
journal of heterocyclic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.321
H-Index - 59
eISSN - 1943-5193
pISSN - 0022-152X
DOI - 10.1002/jhet.2206
Subject(s) - chemistry , domino , chlorosilane , catalysis , aldehyde , scope (computer science) , combinatorial chemistry , cascade reaction , reaction conditions , organic chemistry , silicon , computer science , programming language
A facile and efficient method has been developed for the preparation of seven‐membered heterocycles 1,5‐benzoxazepines 3 by MeSiCl 3 /DMF‐catalyzed domino reaction via the addition of in situ generated enamines to aldehydes 1 . The advantages of this method are that it operates easily and achieves good yields for a broad scope of aldehyde substrates. And the corresponding products can be readily transformed to other categories of compounds, such as the hydrogenated products 4 , which may have potential application in drug industry.