A Facile and Efficient Approach to Seven‐membered Heterocycles by Chlorosilane‐catalyzed Domino Reaction | Zendy

Wang Min | Zendy; Wang Lingtian | Zendy; Guo Qin | Zendy; Ge Junjun | Zendy; Lin Deqing | Zendy; Ye Xiaoxia | Zendy

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A Facile and Efficient Approach to Seven‐membered Heterocycles by Chlorosilane‐catalyzed Domino Reaction

Author(s) -

Wang Min,

Wang Lingtian,

Guo Qin,

Ge Junjun,

Lin Deqing,

Ye Xiaoxia

Publication year - 2015

Publication title -

journal of heterocyclic chemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.321

H-Index - 59

eISSN - 1943-5193

pISSN - 0022-152X

DOI - 10.1002/jhet.2206

Subject(s) - chemistry , domino , chlorosilane , catalysis , aldehyde , scope (computer science) , combinatorial chemistry , cascade reaction , reaction conditions , organic chemistry , silicon , computer science , programming language

A facile and efficient method has been developed for the preparation of seven‐membered heterocycles 1,5‐benzoxazepines 3 by MeSiCl 3 /DMF‐catalyzed domino reaction via the addition of in situ generated enamines to aldehydes 1 . The advantages of this method are that it operates easily and achieves good yields for a broad scope of aldehyde substrates. And the corresponding products can be readily transformed to other categories of compounds, such as the hydrogenated products 4 , which may have potential application in drug industry.

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